Sarraf Deependra Prasad
Poster: Effect of Honey on Rate of Healing of Socket after Tooth Extraction in Rabbits
Will be updated shortly
Objectives: Honey is considered as the oldest known wound dressing. Its wound healing properties is not fully established till today. Some preclinical and clinical studies have suggested that honey may accelerate wound healing in various types of wounds. Reports on the effect of honey on healing of socket after tooth extraction in rabbits are rare. Therefore, the present experimental study was planned to evaluate the efficacy of honey on the healing of socket after tooth extraction in rabbits.
Methods: An experimental study was conducted in six New Zealand White rabbits. Extraction of first premolar tooth on both sides of lower jaw was done under anesthesia produced by ketamine and Xylazine. Honey was applied in one socket (test group) and normal saline (control group) in the opposite socket. The intervention was continued for two more days. On 7th day, biopsy was taken from the extraction socket and histopathological examination was done. Student’s t-test was used for comparison between the groups and differences were considered to be statistically significant at p value less than 0.05.
Results: There was a significant difference between control group and test group in terms of fibroblast proliferation (p = 0.0019) and bony trabeculae formation (p=0.0003). Inflammatory cells were also observed in both groups and it was not significant (p=1.0). Overlying epithelium was hyperplastic in both the groups.
Conclusion: The study showed that local application of honey promoted the rapid healing process particularly by increasing fibroblast proliferation and bony trabeculae.
Gajendra Prasad Raunia
B.P.Koirala Institute of Health Sciences, Nepal
Poster: Antibiotic usage and its culture sensitivity pattern in urinary tract infections at tertiary hospital in eastern Nepal
Prof .Gajendra Prasad Rauniar, Head of dept. of clinical pharmacology and Therapeutics at B.P. Koirala Institute of Health Sciences, Nepal. He is teaching MBBS,BDS and MD(pharmacology) students since last 20 years on organ based , partial problem based . He is actively conducting drug utilization, interventional, antimicrobial study. He is also in-charge for Regional pharmacovigilance monitoring centre at BPKIHS. He did his MBBS from Ranchi medical college and hospital and MD (pharmacology) from JIPMER ,Pondicherry, India.
The presence of microbial pathogens in the urinary tract is UTI (Urinary Tract Infection). In BPKIHS, each year there are around 1000 cases of UTIs. Antibiotic is empirically started after sending culture/sensitivity (c/s) with intention to change antibiotic if c/s demands.OBJECTIVES: To see the antimicrobial prescribing pattern and c/s pattern of UTI inpatients of BPKIHS together with their socio-demographic and laboratory profile.
METHODS: It was a Retrospective study of past one-year. As a convenience sampling, all available inpatient-records from Medical-Record Section were extensively searched for the key word “Diagnosis UTI”. The relevant data were entered in Microsoft Excel-sheet and analyzed with IBM SPSS 21. Ethical clearance was taken from the IRC before study.
RESULTS: There were 86 cases from 4 different wards. There was slight female preponderance (51.16%). Fifty-five (63.95%) cases were complicated. Fever (75.51%) was the most common symptom. Only 20% were tachycardic but 90% were tachypnic. Leucocytosis (59.26%), urine albumin within 30-100 mg/dl (33.85%) and >5 Urine WBC/hpf (80.26%) were seen. Ceftiaxone (50.60%) was the most commonly prescribed empirical antibiotics, followed by Cefixime (9.64%). Fourteen (16.27%) cases were culture positive. E. coli was the most (78.57%) common pathogen grown. In culture sensitivity study, Amikacin (42.85%) was the most sensitive antibiotic.
CONCLUSION: Eighty-six UTI inpatients were identified in the last year. Fever and Tachypnoea were very common. Leucocytosis, 1+ proteinuria and urine WBC>5/hpf were frequently seen. Ceftriaxone was the most common antibiotic prescribed. E. coli was the most common pathogen grown and Amikacin was the most sensitive antibiotic.
Kolon Pharmaceuticals, Inc., South Korea
Workshop Title: Population pharmacokinetics and optimal sampling strategy for model-based precision dosing of bepotastine, histamine antagonist in pediatric patients
WILL BE UPDATED SHORTLY
WILL BE UPDATED SHORTLY